By Farouk Shakib (Eds.)
This ebook positive aspects contributions from across the world popular scientists from Europe and the us masking elements of immunoglobulin subclasses from a molecular and mechanistic process. the 1st part provides a close dialogue of the molecular constitution and segmental flexibility of IgG subclasses, together with how this controls their effector functionality. Structure-function relationships are totally constructed within the moment part through a practical method of the learn of supplement activation and opsonization by means of IgG subclasses. the ultimate part features a beneficiant account of the legislation of IgG subclass expressions
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Additional resources for The Human Ig: G Subclasses. Molecular Analysis of Structure, Function and Regulation
Which have occurred at the coding sequences. SEROLOGICAL A P P R O A C H TO ALLOTYPY Allotypic specificities of immunoglobulins correspond to the antigenic specificities present in some individuals and absent in others of the same species. H u m a n immunoglobulin allotypes are carried by the constant region of K light chains and yl, y2, y3, a2 and e heavy chains. Polymorphism occurs in each of these chains and is dependent on alleles at each locus controlling their synthesis. -P. Lefranc and G.
C. and Wara, D. Monogr. Allergy, 19, 108-121 (1986). 19. WHO, Eur. J. Immunol, 6, 599 (1976). 20. Lange, G. G. de Exp. Clin. , 6, 7-17 (1989). 21. , Steinberg, A. G. and Van-Loghem, E. J. Immunology, 108, 195-206 (1972). 22. Whittingham, S. and Probert, D. N. Monogr. Allergy, 19, 52-70 (1986). 23. Tarrand, J. , Scott, M. , Takes, P. A. and Nahm, M. H. J. Immunol, 9(142) 2519-2526 (1989). 24. Burton, D. , Gregory, L. and Jefferis, R. Monogr. Allergy, 19, 7-35 (1986). 25. Jefferis, R. and Walker, M.
The IgA allotypes and isoallotypes are also given in these t a b l e s . Genetically, the G m system is very polymorphic since 28 allotypes have been described to date, and about 15 are regularly tested. 1 describes 3 135 inhibition method, the allotypes which are revealed by the haemagglutination 3 639allotypes have using polyclonal h u m a n and/or animal a n t i b o d i e s . " Other been recently described using monoclonal a n t i b o d i e s . " The list will probably be expanded. Biochemically, it has been possible to relate some isoallotypes and antithetical (mutually exclusive) allotypes to amino acid substitutions and to very precise peptides.